Natrix Introduces the HD-Sb Hydrogel Membrane Ion Exchanger for Fast and Efficient Purification of Monoclonal Antibodies

Life Sciences
Life Sciences

Burlington, ON, June 25, 2015 – Natrix Separations Inc., a maker of innovative single-use chromatography products for the biopharmaceutical industry, announced today the introduction of its HD-Sb chemistry, a salt-tolerant, strong cation exchange (sulfonic acid) membrane augmented with HIC (t-butyl) groups. The HD-Sb chemistry offers high dynamic binding capacity, even at elevated salt concentrations. The Recon HD-Sb is the first in a line of HD-Sb products to be commercially available. The Recon HD-Sb is a disposable device designed for laboratory-scale purification of monoclonal antibodies and other therapeutic biomolecules.

The new HD-Sb material is based on Natrix’s revolutionary three-dimensional macroporous hydrogel. The open hydrogel structure maintains a high density of available binding sites, achieving high binding capacity comparable to advanced resins but with flow-rates 10 to 20 times higher than resins.

The HD-Sb chemistry is efficient in purifying monoclonal antibodies in flow-through modes, and delivers excellent HCP and aggregate clearance with high monomer recovery. The new Recon HD-Sb is a 0.87 mL column device for lab and screening applications, ready-to-use and compatible with all benchtop chromatography systems.

Natrix HD-Sb products are available through JSR Life Sciences, Natrix’s global distributor. JSR supplies downstream purification products to the bioprocess industry, including its Amsphere™ Protein A chromatography media.

Larger columns incorporating the HD-Sb chemistry are currently in development. These devices will be available soon for scalable purification of monoclonal antibodies from R&D to cGMP manufacturing.

For more information about the new HD-Sb material, please visit:

About Natrix Separations, Inc.

Natrix Separations enables fast and flexible manufacturing of biopharmaceuticals through highproductivity disposable downstream processing products. The innovative Natrix HD Membranes overcome the efficiency, speed, and flexibility barriers imposed by conventional capital-intensive approaches to chromatography. Natrix products feature well-established industry-standard chemistries, and are scalable from R&D to commercial manufacturing. Natrix is headquartered in Burlington, Ontario, Canada. For additional information, visit

About JSR Life Sciences

JSR Life Sciences is a global, Japan-based company built on more than 50 years of polymer expertise and began research in the life sciences more than 30 years ago. Using a variety of integrated, leading-edge technologies, JSR Life Sciences provides materials that contribute to the manufacturing process of biopharmaceuticals, life science research applications, in vitro diagnostics and medical devices. JSR is continually developing highly functional materials and products to meet the current and future needs of the growing biotechnology industry. JSR Life Sciences is part of the JSR Group, a $5B materials technology organization.